New Bremelanotide Results for Women and Video Link
Here's some of the latest information for you to check out...
- A Seattle ABC news affiliate has an article and video report about Bremelanotide and another possible treatment for female sexual arousal disorder.
- The Journal of Neuroscience published a study by researchers from the University of California at Berkeley about how pheromones affect the physiology of women and cause a rise in sexual arousal. (very loosely related to Bremelanotide)
Phase IIa Results (Part 2) for Pre and Post Menopausal Women
Part 2 of Phase IIa trials involving post-menopausal women was presented at the International Society for the Study of Women's Sexual Health (ISSWSH) 2007 Annual Meeting.
Palatin reported women who participated in their study described the significant impact that FSD has had on their lives, their self image, relationships, and to a lesser extent, their mood.
These women also expressed a hope to rekindle sexual desire and their ability to become lubricated.
Along with results for post menopausal women, this presentation also revealed new information about the premenopausal group from the interviews they conducted with them.
These tidbits included:
- women experienced a tingling warm sensation about 10 to 45 minutes after their dose.
- intense arsousal that lasted between 6 to 72 hours.
- feelings of arousal preceded feelings of desire (atypical for those subjects)
- they initiated sex with their partner (also atypical for them)
- and they compared their sexual experience on Bremelanotide to how it was before their FSD symptoms began. Those women also reported they were completely focused on sex during the act.
27 women took part in post menopausal group of the Phase IIa study, and completed a 'subjective' questionaire 10 minutes before their dose, 25 minutes after the dose, 55 minutes after the dose, and a "treatment satisfaction index" completed at home 24 hours after the dose.
There was also an in-depth ~30 minute interview with 20 of the postmenopausal women in Hackensack, NJ and Cleveland, OH.
Quotes from Postmenopausal Women Treated with Bremelanotide
"It was like when we were dating in 30's and 40's"
"I was 100% into it; I was in the mood"
"I was focused on sex. I wasn't thinking of anything else"
" Improvement in the quality of Climaxes: more intense, lasted longer, able to climax multiple times, more natural."
"Climax was more natural; like pre-menstrual"
"My climax was like it used to be"
"(Climax) quality was better - more intense, lasted longer."
"(Was) able to climax multiple times. That's not usual."
"Ability to orgasm was even easier than when I was 30"
Adverse Affects in Phase IIa Subjects
Similar to earlier results, there were some adverse effects in this phase of the trials in this group. Here are the percentages of women who experienced the indicated problems with their dose of Bremelanotide and the Placebo group (as a comparison)...
My Comments: It appears a small percentage of women likely experienced most or all the adverse effects, since the less common problems all show 7.4% of the subjects had them.
It's also quite possible that administering a lower dose will lessen or remove these effects, similar to what the Bremelanotide Phase IIb men's trial revealed.
You can see Palatin Technologies' Power Point presentation from the International Society for the Study of Women's Sexual Health 2007 Conference by clicking here.
Seattle ABC News Affiliate Reports on Bremelanotide
KOMO TV in Seattle, where apparently some elements of the Bremelanotide Trials are being done, filed a report entitled: "Local research aims to boost women's libido".
The article is quite interesting to read, and both it and the accompanying video reveals some new insights into the Bremelanotide trials.
One of the women taking one of the drugs mentioned in the article wrote KOMO TV a letter that reveals how FSAD is both a personal and an intense problem for women...
"I love my husband. He is more laid back than me. We get along great.
"About seven years ago, I noticed that my interest in sex seemed to fade and it has more or less gone away. Our intimate encounters are about once a month now and it used to be more than once a week! I hope I can fix it."
Dr. Robin Kroll of the Women's Clinical Research Center in Seattle said about female sexual arousal disorders:
"It can cause a great deal of discord (and) it can cause marital problems.
What I try to explain to my patients who come to me with sexual dysfunction, is by the time they come to me, there are already relationship issues."
Another Treatment Being Tested for FSAD
The KOMO TV article also mentions another drug being tested for possible treatment of Female Sexual Arousal Disorder called Flibanserin.
I will begin tracking development of this drug along with Bremelanotide, and will ensure future issues report on any new results or news for that drug as well.
My preliminary research revealed one big difference between the two drugs, specifically that Bremelanotide is a quick acting, short term method to increase arousal.... whereas Flibanserin seems to act more like standard antidepressants like Paxil or Prozac - in the sense it has to be taken for a lengthy period of time before the effects are felt (ie around 4 to 6 weeks) but stays in the system from that point onward as long as the treatment continues.
And their video report, also available on the above page, can be viewed here.
Phermones Affect Physiology of Women...
Cause Rise in Sexual Arousal
The Journal of Neuroscience published a study by researchers from the University of California at Berkeley on how Phermones affect the physiology of women and cause rise in sexual arousal.
Here is an excerpt from the Louisiana State University newspaper, The Daily Reveille:
A study published this week in the Journal of Neuroscience by researchers from the University of California at Berkeley reported men emit chemical compounds in their sweat that affect the physiology of women.
These compounds, called pheromones, have been researched for years to determine their effects on other humans, specifically members of the opposite sex.
According to the study conducted last year, 48 undergraduate women took 20 sniffs from containers of androstadienone, a main component found in male sweat, auxiliary hair, blood and semen secretions.
After testing the levels of cortisol, an adrenal hormone, results showed heightened energy and increased blood pressure that remained at high levels for over an hour, when compared with the sniffing of a controlled odor.
During the test, the female participants had a rise in blood pressure, heart rate and sexual arousal.
John Hogan, chemistry instructor, said researchers realized years ago that animals emitted similar chemical pheromones which affected behavior.
"These compounds aren't actually smelled but picked up by receptor sites in the nose, which emit the chemical to different parts of the brain," Hogan said.
Although this physiological reaction is not related to the way Bremelanotide works on both men and women, it is certainly an interesting study and seems to further bolster the research and press reports linked to on the pheromone cologne website that I've mentioned in previous Bremelanotide Bulletins.
I'm hoping to report on more successful Bremelanotide trial results in the very near future!
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New Bremelanotide Results for Women and Video Link